Estación Biológica Cocha Cashu

Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts

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Revista Científica:

Journal of Ethnopharmacology

Año:

2009

Número:

123

Páginas:

413-422

DOI:

10.1016/j.jep.2009.03.041

Keywords (Autor):

Yanesha, Plasmodium, Leishmania, Leishmanicidal agents, traditional medicine, antimalarial, Peru

Resumen

Aim of the study: Ninety-four ethanolic extracts of plants used medicinally by the Yanesha, an Amazonian Peruvian ethnic group, for affections related to leishmaniasis and malaria were screened in vitro against Leishmania amazonensis amastigotes and against a Plasmodium falciparum chloroquine resistant strain. Materials and methods: The viability of Leishmania amazonensis amastigote stages was assessed by the reduction of tetrazolium salt (MTT) while the impact on Plasmodium falciparum was determined by measuring the incorporation of radio-labelled hypoxanthine. Results and conclusions: Six plant species displayed good activity against Plasmodium falciparum chloro quine resistant strain (IC50

Autor (es ):

Valadeau Céline, Pabon Adriana, Deharo Ericb, Albán–Castillo Joaquina, Estevez Yannick, Lores Fransis Augusto, Rojas Rosario, Gamboa Dionicia, Sauvain Michel, Castillo Denis, Bourdy Geneviève

Idioma:

Inglés

Tipo de Referencia:

Articulo de revista academica

Investigadores: